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As the focus of this article is on innate immunity, we limit our discussion of the probable therapeutic implications of MIF to sepsis and ARDS. Constitutively expressed by a broad spectrum of check here cells and tissues, including monocytes and macrophages, MIF is promptly introduced soon after publicity to microbial solutions and pro-inflammator

In recent years, sizeable development has been produced in delineating the mechanisms by which inflammatory cytokines as well as their receptors aid tissue maintenance and regeneration. This mini evaluate concentrates on rising literature about the position in the cytokine macrophage migration inhibitory variable (MIF) and its cell membrane recepto